PDF Harold E Buttram, MD and Catherine J Frompovich
Harold Buttram, MD
June 1, 2011
Inflammation
Inflammation is a biochemical process resulting from pathogens, irritants, or damaged cells. It should not be compared to infection, although inflammation can result from infection. A cascade of biochemical events propagates and matures the inflammatory response, involving the local vascular system, the immune system, and various cells within the injured tissue. [1] [Emphasis added]
Several diseases have their origin in the inflammatory process: Alzheimer’s [2], coronary artery disease [3-6], and cancer. [7-9] Other disorders with which inflammation is associated include acne vulgaris, asthma, autoimmune diseases, chronic prostatitis, glomerulonephritis, hypersensitivities, inflammatory bowel disease, pelvic inflammatory disease, reperfusion injury, rheumatoid arthritis, transplant rejection, vasculitis, interstitial cystitis. Inflammation, therefore, is well known in the etiology of disease.
Furthermore, inflammation is a protective attempt of the organism to remove harmful stimuli and is achieved by the increased movement of plasma and leukocytes (especially granulocytes) to initiate healing. [10]
Encephalitis is an acute inflammation of the brain, usually associated with meningitis. Some symptoms associated with encephalitis include fever, drowsiness, fatigue, and convulsions. The primary diagnostic procedure is a lumbar puncture with removal of cerebrospinal fluid for culture and microscopic analysis.
Another aspect of encephalitis known as Rasmussen’s encephalitis causes chronic inflammation with infiltration of T lymphocytes into the brain leading to atrophy and epilepsy.
Several viruses including polio, chicken pox, and West Nile are capable of causing encephalitis.
And, an allergic reaction to vaccinations [11], as per the National Institutes of Health, also can cause encephalitis with brain swelling. Encephalitis was included as one of the vaccine injuries to be compensated for under the 1986 National Childhood Vaccine Injury Act. [12]
Vulnerabilities of the Infant Brain, Uniquely Susceptible to Lipid Peroxidation
By way of explanation, the term “lipid peroxidation” refers to lipid degradation resulting from free radical generation from a series of pro-inflammatory chain reactions, which can be very damaging if the process is prolonged. “Free-radicals” in turn refer to atoms with unpaired electrons, resulting in heightened instability and reactivity. The end result of abnormally prolonged lipid peroxidation may be abnormal brain inflammation with secondary brain edema (swelling).
Of all the organs of the body, the brain is the most susceptible to oxidative degradation, commonly referred to “lipid peroxidation.” Although an infant’s brain receives 15 percent of normal cardiac output, it utilizes nearly 25 percent of the body’s oxygenation. [13] As elevated oxygen levels in the environment bring increased risk of explosions or fire, comparable physiological risks exist in the brain. In addition to being a highly oxygenated organ, the human brain has heightened vulnerability to harmful peroxidation because the brain has by far the highest fat content of any organ of the body with membrane lipids constituting 60 percent of the solid matter. [14] In addition, both brain and retina contain a relatively high percentage of the omega-3 polyunsaturated fatty acid, docosahexaenoic acid (DHA) [10-20] and arachidonic acid (ARA) that serve as a primary building block of the membranes of these structures. DHA and ARA are high in energetics, but they are far more unstable and vulnerable to pro-inflammatory peroxidation (oxidative lipid degradation) than saturated fats. [13-22]
In essence, the brain might be compared with highly inflammable dry grass or brush enclosed in an area with elevated oxygen levels, needing only a spark to set off a conflagration of inflammatory lipid peroxidation. In all likelihood, vaccine adjuvants provide this spark far more often than generally realized.
The Pourcyrous Study: A Major Milestone in Medical History
A study on primary immunization of 239 premature infants with gestational ages of less than 35 weeks by M. Pourcyrous et al. (Journal of Pediatrics, 2007) [23] was conducted to determine the incidence of cardio-respiratory events and abnormal C-Reaction Protein (CRP) elevations associated with administration of a single vaccine or multiple vaccines simultaneously at or about two months of age. The vaccines given were: DTaP (Infanrix), Hib (ActHIB), HBV (Engerix-B), IPV (Inactivated-IPOL™), and PCV7 (Prevnar).
CRP is a standard blood test indicator for body inflammation, which in the present study would represent brain inflammation. CRP levels and cardio-respiratory manifestations were monitored for three days following immunizations in a neonatal intensive care unit sponsored by the University of Tennessee. Elevations of CRP levels occurred in 70 percent of the infants administered single vaccines and in 85 percent of those administered multiple vaccines, 43 percent of which reached abnormal levels.
As the Pourcyrous study noted,
A plausible explanation for variation in the magnitude of CRP responses to immunization may be attributed to viral versus bacterial antigenic stimulation, minor variability in the quantity of antigens in different vaccine lots, the multiple antigenic component of a vaccine, the presence and the quantity of aluminum adjuvant, genetic polymorphism or to decrease immunologic responses in some preterm infants. [24]
Overall, 16 percent of infants had potentially lethal vaccine-associated cardio-respiratory events with episodes of apnea (cessation of breathing) and/or bradycardia (abnormal slowing of the pulse). Intraventricular (brain) hemorrhages occurred in 17 percent of those receiving single vaccines and in 24 percent of those receiving multiple vaccines.
Pourcyrous, et al. further indicated that
Other investigators also have reported on cardiorespiratory events following immunization with DTaP-based multivalent vaccines or when DTaP was given simultaneously with other vaccines. Omenaca et al. after excluding from their study infants with chronic illnesses and using only one lot of combination vaccine, observed cardiorespiratory events in 42% of infants with BW [body weight] <1000 g. [25]
Furthermore, the Pourcyrous study noted that the DTaP vaccine was associated with the highest incidence of cardio-respiratory events in those infants given a single vaccine.
1. Brain inflammation as indicated by elevated C-Reactive Protein tests.
2. Brain swelling (edema) as one of the cardinal signs of inflammation.
3. Potentially lethal cardio-respiratory events.
4. Brain hemorrhages.
The Pourcyrous study also raises a question. Why were the brain hemorrhages in the Pourcyrous study intraventricular rather than subdural, the latter almost invariably being attributed to Shaken Baby Syndrome/Non-Accidental Injury (SBS/NAI) in hospital emergency rooms in the absence of a known major accidental trauma. The answer is that the Pourcyrous study was performed on preterm infants, some born less than 30 weeks term, in whom intraventricular hemorrhages are known to be characteristic. This may be due, at least in part, to the infant brain/skull interactions at different stages of development. In preterm infants the skull would be highly flaccid, providing little if any resistance to a swollen (edematous) brain.
Early animal studies have shown that brain inflammation frequently ensues following vaccines and is also commonly associated with brain hemorrhages.[26-28] In term infants, in contrast to preterm births, the inner surface of the skull presents a relatively firm surface, and when brain inflammation and swelling take place from vaccines, it would require very little swelling for the outer surface of the brain to impact against the inner surface of the skull and, tourniquet-like, cut off the passive outflow of blood from the subdural venous network. With cranial arterial blood coming in at much higher pressures, this would predictably cause a precipitous rise in intra-cerebral venous pressure, the true cause of many subdural hemorrhages.
According to a report by W. Squier and J. Mack (2009) [29], most childhood subdural hemorrhages are identified in infants 0-4 months of age, a time when the subdural compartment consists of 10-15 layers of loosely arranged flake-like cells with fluid between them and few intercellular junctions. [30] Under these highly permeable conditions it is predictable that a rapid surge of intracerebral venous pressure would force blood from the subdural venous network into these loosely connected subdural membranes, the true cause of many subdural hemorrhages now being erroneously attributed to Shaken Baby Syndrome/Non-Accidental Injury.
Proinflammatory Vaccine Adjuvants
Adjuvants Defined
Vaccine adjuvants are substances added to vaccine formulations during the manufacturing process that are designed to boost and prolong the overall immunological responses to vaccines. This results in a priming of the brain’s immune cells, the microglia and astrocytes, followed by intense microglial and astrocyte reactions with each successive series of vaccination. As reviewed by Viera Scheibner, PhD, there are three general classes of adjuvants:
1. Aluminum: Aluminum phosphate, Aluminum hydroxide, Aluminum hydroxyphosphate sulfate, and Aluminum potassium sulfate
2. Various oils including Freund’s emulsified oil, mineral oil, emulsified peanut oil (adjuvant 65), and squalene (shark oil),
3. Bacterial products including Bordettella pertussis (whooping cough), Mycobacterium (tuberculosis), cholera toxin, and others. [31] Adjuvants in various vaccines are listed on vaccine package inserts. [32]
In what may be the most comprehensive review to date on the pathophysiology of adverse vaccine reactions, neurosurgeon Russell Blaylock has compiled a mass of evidence that repeated stimulation of the brain’s immune system results in intense reactions of microglial and astrocyte cells, which serve as the brain’s immune system, with each successive series of vaccinations. This is primarily the result of vaccine adjuvants that are added expressly for immune stimulation purposes. [33-35]
In explanation, microglia and astrocytes are first-line immunological responder cells located in the brain that defend against foreign infectious invaders. Normally this response, such as to a viral infection, is of limited duration and harmless to the brain. However, when microglia and astrocytes are over-stimulated for prolonged periods, which vaccine adjuvants are designed to bring about, this extended activation can be very destructive to the brain causing inflammation and/or bleeding.
Because of the critical dependence of the developing brain on a timed sequence of cytokine, and excitatory amino acid fluctuations, according to Blaylock, sequential vaccinations can result in alterations of this critical process that will not only result in synaptic and dendritic loss, but abnormal (nerve) pathway development.
When microglia are excessively activated by vaccines, especially chronically, they secrete a number of proinflammatory cytokines, free radicals, lipid peroxidation products, and the two excitotoxins, glutamate and quinolenic acid, which may become proinflammatory and highly destructive when activated for prolonged periods.[33] [Emphasis added]
This process was suggested as the principle mechanism resulting in the pathological as well as clinical features of autism.
As a potential connecting link between vaccines, brain inflammation, and autism, Diana Vargas and colleagues (2005) [36] examined the brains from autopsies of 11 autistic patients ranging in ages from 5 to 44 years, in which they found the presence of extensively activated microglia and astrocytes (the brain’s immune cells) along with proinflammatory cytokines.
Normally dormant, the microglia and astrocytes can become very destructive when overstimulated for prolonged periods of time, which vaccine adjuvants are designed to bring about. As with the Pourcyrous study, it was the first study of its kind, clearly documenting a significant association between autism and brain inflammation.
For many years two forms of aluminum, aluminum hydroxide and aluminum phosphate, were the only compounds specifically authorized by the FDA to be used as vaccine adjuvants. These virtually insoluble aluminum compounds serve to dramatically boost and prolong the immune reaction to the vaccination by prolonged activation of the macrophagic immune sub-system in some people. [33-45] Currently four forms are used in vaccines according to the Centers for Disease Control and Prevention (CDC).
Because vaccine adjuvants are designed to produce prolonged immune stimulation, they pose a particular hazard for the nervous system. Studies have shown that immune activation following vaccination can last up to two years, which means that destructive over-stimulation of microglia may also be primed for this length of time or even longer. In addition, it is known that aluminum accumulates in the brain and that this accumulation is associated with Alzheimer’s and Parkinson’s diseases and with Gulf War Syndrome. [43-45]
As pointed out by L Tomljenjovic and CA Shaw:
“Aluminum is an experimentally demonstrated neurotoxin and the most commonly used vaccine adjuvant. Despite almost 90 years of widespread use of aluminum adjuvants, medical science’s medical understanding of their mechanisms of action is still remarkably poor. There is also a concerning scarcity of data on toxicology and pharmacokinetics of these compounds. In spite of this, the notion that aluminum in vaccines is safe appears to be widely accepted.” [66]
Experimental research, in contrast, clearly shows that aluminum in adjuvant form…carries a risk for autoimmunity, long-term brain inflammation and subsequent neurological complications and may thus have profound and widespread adverse health complications. [66]
Unlabeled Peanut Oil
In a newly released book, The History of the Peanut Allergy Epidemic [46], Heather Fraser thoroughly documents how highly allergenic peanut oil came to be used in vaccinations without being listed on the package insert. With her background as a historian and mother of a child that required repeated hospitalizations for severe peanut allergy, Ms. Fraser wrote from personal knowledge and experience.
The first use of peanut oil in vaccines was reported in 1964 by The New York Times, which announced that pharmaceutical giant Merck had begun to use a new vaccine ingredient that promised to extend immunity against influenza, polio, and other illnesses. [47] When injected into the muscle, the oil was gradually metabolized by the body providing a sustained release of the other ingredients and producing 13-fold higher levels of antibodies than had formerly taken place from aqueous vaccine formulations. [48]
In the 1970s and 1980s, following modifications of the original adjuvant 65-4, the use of peanut oil in vaccines became common practice. [49-51]
As tabulated by Heather Fraser, it was during this time period that the incidence of peanut allergies began to rise in exponential proportions, as did the incidence of Guillain-Barré Syndrome. [51]
Toxic Environmental Chemicals and the Work of Rachel Carson
In the 1960s Rachel Carson’s Silent Spring sent a shudder through our nation’s spine as she quietly warned of growing environmental havoc brought about by our advancing technology, largely involving hundreds of petrochemical-derived products (pesticides, etc.), which are fat-soluble and therefore of foremost danger to the brain and nervous system. Although there has been some recognition of the dangers from these chemicals, there appears to be little awareness that toxic environmental chemicals of commercial origin may be replacing infectious microorganisms as the primary threat to human health and life on this planet. [52] One research area in which these dangers are being graphically demonstrated is in animal studies reporting losses of cerebellar neurons and Purkinje cells resulting from alcohol and/or OXR-saporin administration. [53-55]
Vitamin C and Cardiovascular Disease
As reported by TE Levy in “Vitamin C and Cardiovascular Disease” (Townsend Letter, 2011) [56], the author makes the case that atherosclerotic coronary artery disease begins with severe depletion of vitamin C in the intima (connective tissue and collagen) of the coronary arterial wall. In the degenerative state of atherosclerosis, there is always a loss of the gel-like nature of the arterial basement membrane.
As described by Levy:
“The proliferative state of atherosclerosis comprises the longest or most extended phase of plaque development. Once the basement membrane has lost its gel-like nature, the endothelial cell layer has become more porous, and the sieve-like nature of its collagen mesh has lost much of its integrity, there is a steady invasion of blood solutes like calcium, lipids, fats, and even pathogenic microbes with their associated toxins. Such microbes often, but not invariably, originate from dental foci.”
If the above information is applied to the area of brain inflammation, with pro-inflammatory vaccine adjuvants rapidly depleting vitamin C, which is already marginal in a large portion of our society [57], we have a ready explanation for the 70 percent elevations of C-Reactive Protein with single vaccines and 85 percent elevations with multiple vaccines. For these reasons the Pourcyrous study will remain incomplete until plasma vitamin C levels are also tested following vaccines as a part of the study.
As the Pourcyrous study points out, cardio-respiratory events occurred within 48 hours in preterm infants vaccinated while in hospital, indicating that there were no Shaken Baby Syndrome nor Non-Accidental Injury incidents that could influence those cardio-respiratory events, which parents apparently also can experience at home after children are vaccinated and for which they seek hospital emergency room treatment for their child.
Vaccines, Vitamin C Depletion, Brain Inflammation, and the Current Epidemic of Childhood Autism
As described above, it is well established that chronic tissue inflammation tends to be associated with tissue destruction and/or malignant degeneration. The section on cardiovascular disease by TE Levy showing a correlation between tissue degradation of coronary arteries and vitamin C depletion provides a major advancement in our understanding that has long been stressed by earlier pioneers in this field. Although scientific research into the potential therapeutic role of vitamin C for degenerative diseases remains in its infancy, some things are already known including studies showing that hydroxylation (oxidation) of proline and lysine into procollagen is carried out by the enzyme prolyl hydroxylase, which requires vitamin C as a cofactor. [59-60]
Although lacking in meaningful NIH-sponsored vaccine safety tests to date, there is a substantial body of circumstantial evidence that vaccines are causally related to the current childhood autism epidemic, the sum total of which shifts the balance into “more likely than not within a reasonable degree of medical certainty.”
- Several autism-free zones exist in the United States in what is otherwise a sea of childhood autism. Most prominent among these are Amish communities in Pennsylvania and Ohio where parents rarely vaccinate their children. The only exceptions were several vaccinated children that were adopted. [61]
- “Analysis finds Evidence of Autism in Many Vaccine Injury Cases” [62] For years, government health officials and most other medical authorities have dismissed the idea that autism might be linked to childhood vaccines; and the special court set up by Congress to compensate people hurt by vaccines has denied thousands of claims over the past decade by parents who have contended that their children developed autism because of their inoculations. But a new report in a New York law school journal, the Pace Environmental Law Review, [67] could re-ignite the often-inflammatory debate over the issue. Based on a sampling of cases in which plaintiffs won settlements or awards in vaccine court, the authors found that many of the victims demonstrated evidence of autism even though—as a legal tactic—their lawsuits emphasized other injuries. Of the 170 cases the report’s authors examined, 32, or 19 percent, provided documented evidence of autism or autism-like symptoms. The evidence in some included that the court found evidence of autism or “autism-like symptoms”… or that third-party medical, educational, or other court records confirmed an autistic disorder.
- Fox Morning News, 11 May, 2011, 8:27AM: (Fox25/MyFoxBoston.com): Congress will hold hearings Thursday about a possible link between childhood autism and vaccination—a thought that many thought had been put to rest earlier this year when the Centers for Disease Control and Prevention released a study suggesting that research does not point to an association between the two. But according to information discovered in documents by safeminds.org, at least 83 families received federal compensation for vaccine-related injuries, and each of these 83 children suffered from autism.
- Few are aware of the fact that the measles, mumps, and rubella vaccines were administered separately for a number of years in the USA with only slight increases in the incidence of childhood autism prior to the introduction of the MMF vaccine in 1979. It was only following the introduction of this triple vaccine that the incidence of childhood autism showed a sharp and dramatic increase. [63-64]
Gross Deficiencies in State-of-the-Art Vaccine Safety Tests
During the Congressional Hearings on Vaccine Safety (1999-Dec. 2004) an FDA panel was repeatedly asked, “Where are your (safety) studies?” The panel could only reply with unsatisfactory answers such as, “They would be very expensive.” However, it was not until January 14, 2009 that it became evident that the avoidance of meaningful vaccine safety studies has long been an established policy by the National Institute of Health, the primary federal agency responsible for funding health research in the United States, as reported by the autistic support group, Age of Autism:
January 17, 2009
National Autism Association on IACC Removal of
Vaccine Safety Research, A Press Release from
The National Autism Association:“Washington, DC – In an unprecedented move on Wednesday, Jan. 14th, the Interagency Autism Coordinating Committee (IACC) removed previously approved vaccine safety research from the Strategic Plan for Autism Research objectives. With apparent backing from the CDC representation, committee chair and HIMH director Tom Insel implied that vaccine research conducted by the National Institutes of Health (NIH) would constitute a conflict given the involvement of Health and Human Services with ongoing autism cases filed in the federal vaccine court. The committee’s action is in direct opposition to the majority of its public members who support vaccine research, and to the Congressional directive of the Combating Autism Act of 2006 (CAA) which specifically called for research into potential links between vaccines, vaccine components, and the autism spectrum disorder.
“ ‘In addition to the CAA’s mandate for vaccine research, the legislation specifically called for the establishment of key research activities to arrive from meaningful public involvement and advice through the IACC which includes both government and private representatives.
“ ‘Ignoring the Congressional mandate for investigation to links between vaccines and the development of autism is a slap in the face to both Congress and the citizens of this country’, said National Autism Association board chair and parent Lori Mellwain. ‘Even the most basic studies comparing health outcomes of vaccinated vs nonvaccinated populations are consistently ignored despite the increasing support for them from legislatures, physicians, and parents.’
“ ‘Dr. Insel’s observation that the NIH is incapable of conducting conflict-free research supports what a growing number of parents believe,’ commented Ms. Mellwain. ‘While the motivation for refusing to allow this critical research to go forward is likely more related to fear of what such studies would reveal, it is clear that the system managing our vaccine program is corrupt beyond repair and needs a complete overhaul.’” [58]
Based on these revelations, the claims of health authorities that there is no proof of a relationship between vaccines and autism has been technically correct, but this is only because the tests which could prove such a relationship have been systematically and knowingly avoided by the NIH and other government health agencies over a period of many years, which is confirmed by the above declaration by the National Autism Association.
However, since the U.S. Congressional Hearings on Vaccine Safety, 1999-December, 2004, which found gross deficiencies in vaccine safety testing, steadily increasing numbers of highly reputable studies have been appearing in the medical literature indicating that significant harm may be taking place from current childhood vaccine programs. The Pourcyrous study cited above [1] is offered as a prime example.
Safety Recommendation for Parents Who Choose or are Mandated to Vaccinate Their Children, Based on Guidelines of the Autism Research Institute
- Never vaccinate a sick child, even if just a runny nose from a viral infection, as all viruses are immunosuppressive, rendering the child more vulnerable to adverse vaccine reactions.
- Never allow more than two vaccines per visit; avoid all combination vaccines.
- Administer vitamin C before and after each vaccination, ideally in doses of 500 mgs every four hours during waking hours. Also give vitamin A in standard doses.
- All forms of sugar should be avoided for several days before and after vaccines, as sugar has been shown to diminish the protective activities of the immune system by depressing white blood cells’ ability to destroy bacteria. [65]
Conclusion
The Pourcyrous study confirms cardio-respiratory events occurred within 48 hours of vaccination for preterm infants in a hospital neonatal intensive care unit where no other conditions such as Shaken Baby Syndrome (SBS) or Non-Accidental Injury (NAI) presented. That study also indicates a standard medical test, C-Reactive Protein, can be used to check for and confirm inflammation associated with brain trauma resulting from vaccine adverse reactions such as cardio-respiratory events.
The roles of prenatal dietary vitamin C and birth trauma also must be considered in infant brain anomalies instead of Shaken Baby Syndrome or Non-Accidental Injury that hospital emergency room doctors are quick to give as diagnoses in infants who suffer adverse vaccine reactions, especially when no physical trauma is present on the body.
On vaccine package inserts, cardio-respiratory events such as those documented in the Pourcyrous study, e.g., apnea, bradycardia, gastroesophageal reflux, hemorrhage / inflammation of the brain, and oxygen desaturation, must be listed under contraindications or adverse reactions.
Vitamin C blood levels can be helpful in determining post-vaccination brain inflammation occurrences. Furthermore, the importance of proper vitamin C levels is suggested as possible prevention for cardio-respiratory events post-vaccination in both preterm and term infants. Vitamin C correlates directly with prenatal nutrition and the pregnant mother’s diet being nutrient rich in fresh fruits and vegetables.
International Medical Council on Vaccination │www.vaccinationcouncil.org
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59. Qutob S, Dixon S.J., and Wilson, J.X. Insulin stimulates vitamin C recycling
and ascorbate accumulation in osteoblastic cells, Endocrinology, 1998; 139(1):51-56.
60. Stone N, Meister A. Function of ascorbic acid in the conversion of proline to collagen hydroxyproline, Nature, 1962; 194:555.
61. Olmsted, Dan and Mark Blaxil, The Age of Autism, Mercury, Medicine, and a Man-Made Epidemic. New York. Thomas Dunne Books, St. Martin Press. 2010: 252-253.
62. http://sz0062.we.mail.comcast.netzimbra/h/printmessage?id=243629&id=1.
63. Sources: Centers for Disease Control and Prevention, California Dep’t of Health and Human Services.
64. Miller NZ, Vaccine Safety Manual, 2008; Sante Fe, NM: New Atlantean Press, p.102.
65. Sanchez A et al. Role of sugars in human neutrophil phagocytosis, American Journal of Clinical Nutrition.1973; 26:1180.
66. Tomljenovic L and Shaw CA. Aluminum vaccine adjuvants: Are they Safe? Current Medicinal Chemistry. 2011; 18: 2630-2637.
67. Holland Mary, Louis Conte, Robert Krakow and Lisa Colin. Unanswered Questions From the Vaccine Injury Compensation Program: A Review of Compensated Cases of Vaccine-Induced Brain Injury. Pace Environmental Law Review, Vol.28, Issue 2, Winter 2011, pp.480-544. http://digitalcommons.pace.edu/peir/vol28/iss2/6
Great article! Very informative and straightforward. Keep up the great work!
Knckoed my socks off with knowledge!
Wow – I’ve read this twice – what great information, stunning knowledge. I’m off to bed – getting on my dressing gown ready for another read!
Thanks for this
Emma B.
MD – As
Thanks for the great chapter on inflammation, which is surely at the core of the damage caused by vaccines drugs, and food. Then, when the brain is vulnerable due to the breakdown of it’s immunologic integrity, and natural barriers, bacteria gets in. Then they call it bacterial meningitis. And when neurotoxins get in, they call it autism. But really it is vaccine induced brain inflammation and secondary infection/autism. So much poorly interpreted “science” in the textbooks and propagated by parroting practitioners. Your writing is a great antidote to the warped teachings in medicine. If only the medical schools would adopt this chapter in it’s pharmacology unit. Thanks.
Haha, shouldn’t you be charging for that kind of konwlegde?!
Let me join in the chorus by saying Great article! VERY thought-provoking and timely. The Pourcyrous study is certainly a milestone in understanding vaccine toxicity, and thank you for presenting it. I don’t know how I could have missed the article! The “cascade of biochemical events” that the authors refer to, needs to be better understood. It is likely to be shared as a common underlying pathophysiology of all vaccine toxicity. The fact that many, if not most, SIDS deaths are vaccine-induced, is a case in point. The terrain is everything.
Dr. Buttram and Catherine,
Thank you for covering such an important topic. I would specifically like to comment specifically on brain inflammation after vaccination, otherwise known as ‘Post Vaccinal Encephalitis’.
When I first started to research this aspect of adverse reactions to vaccines, the impression was it was a rare event. However, even reviewing literature decades old shows it was a very real and documented problem even in the early 1900s. Let me share a few examples:
Post-Vaccinal Nervous Disease. Lancet. April 24, 1926; pp. 874.
Post-Vaccinal Encephalitis. -The Services. Lancet. March 19, 1927; pp. 617.
Post-Vaccinal Encephalitis – Report of the League of Nations Commission. Lancet. Sep. 29, 1928; pp. 674
A Fatal Case of Post-Vaccinal Encephalitis. Lance. Sep. 21, 1929; pp. 636.
Grace, A. A Case of Post-Vaccinal Encephalitis in British Guiana. Transactions of The
Royal Society of Tropical Medicine and Hygiene, Vol XXIII. No.4, Jan., 1930. pp. 427-428.
Post-Vaccinal Encephalitis. Lancet. March 8, 1930; pp. 525.
Post-Vaccinal Encephalitis – A Review of Recent Data. Lancet. Jan. 10, 1931;pp. 97-98.
Observations on Post-Vaccinal Encephalitis. Lancet. June 13, 1931; pp.1307.
Incidence of Post-Vaccinal Encephalitis. Lancet. May 2, 1936; pp. 1022.
Jacobs, H.Report of a case of postvaccinal encephalitis in a four-month-oldchild with recovery. Jrnl of Pediatrics, Vol. 35:1; July 1949; pp. 94-98
Jenkins, J. Postvaccinal Encephalitis. Am. Jrnl of Nursing, Vol. 50, No. 9; Sep., 1950; pp. 518-521
Since vaccines have almost been given carte blanche immunity from scrutiny in the medial community, I would highly suspect that many physicians today would be slow to correlate symptoms of encephalitis and recent vaccination.
Keep up the excellent work.
Information is power and now I’m a !@#$ing dicttaor.
First, this article was very interesting and informative as far as it went.
However, as a researcher in the area of vaccines, I was taken aback by the failure of the article to address the mercury-based compound sodium ethylmercurithiosalicylate, having the trade names Thimerosal, Merthiolate, Thiomersal, Timerosal, etc., that is still used as a preservative in several of the vaccines for developing children in most of the world and in the majority of flu shots and some other vaccines for pregnant women, developing children and adults in the USA.
The reason for my dismay is that Thimerosal is a strong “antigen” and immune-system disregulator in addition to being a known human carcinogen, mutagen, teratogen and systemic poison. In fact, in most research studying allergen prevalence, Thimerosal is the second-most-common allergic-reaction-producing compound (after nickel sulfide). In addition, unlike methylmercury chloride and hydroxide, Thimerosal appears to be a strong autoimmune inducer (e.g., apparently increasing the risk of hepatitis-B-induced multiple sclerosis (MS) by a factor of 3 for the Thimerosal-preserved hepatitis-B vaccine [now-GSK’s Energix® B] over the comparable no-Thimerosal hepatitis B vaccine used in the French middle-school vaccination program).
Moreover, Thimerosal exerts these effects at sub-ppm levels — levels much lower than the levels in the vaccines for the vaccine adjuvants that the article did address.
Hopefully, in some future article, the authors of this article will address the preceding realities and/or explain why they chose to overlook one of the many roles of Thimerosal in the “poisoning” of many of the biochemical processes that control immune-system function.
Just my 2 cents.
Neither did he mention that monosodium glutamate (MSG) has been added to the vaccines now as a preservative, but they still left the thimerosal in there. MSG is one of the two major excitotoxins that our food supply is rife with.
However this is a great article and one that every lawyer going to court to battle for compensation for the harmful reaction or death of the vaccinated. Even more important is that parents acquire this knowledge in order to not vaccinate their children, thus not creating the damage to the child and not requiring the lawyers services. The ex-planation of the pathology of the reaction is excellent, but for me the most important thing in this article is the statement that while most of the US is rife with autism, there are autism free areas, and proceeds to mention that 2 Amish communities in Ohio and Pennsylvania where parents don't vaccinate have no autism at all. If this is true, and I believe it is, this itself is irrefutable proof that it is the vaccines causing the autism and other problems.
Joyce, these are great points. Thank you! -nh
I saw another article that dealt with Thimerosal.
What can one say.
Great paper, great experts and real serious ones as opposed to those with AGENDAS.
Can’t cover everything in one article as mentioned by comments on mercury and essentially ANAPHYLAXIS.
I am endeavouring to find more on peanut oil sensitivity and note the 1954 September Merck patent to inject this into humans. Difficult to find more on the net other than a short comment found here.
I am confident that this must be close to the zero line for when people started to die from such oil and an ANAPHYLACTIC effect already alluded to. As a child no one knew of peanut allergies back in the days before this date. Today the whole world reads of sudden death even by kissing a peanut eater et al.
Charles Richet, Nobel Winner has an early book on ANAPHYLAXIS and 100 years on we still know his work in this field was correct. Reading his work and then looking at repeat vaccines makes one wonder if one is sane and if government, industry and regulators are INSANE?
This very ancient but still VITAL work helps explain why people can now die from an essentially good food product and why problems occur after second and third vaccines the same.
Simple science, common sense ABANDONED and just continue with the now one million SIDS and INCREASING which we pretend not to know the reason for but somehow know that proven harm from the time of Charles Richet can be ignored with IMPUNITY.
Such is the protection given to those that practice legal GENOCIDE.
Dr. King,
I agree with your stance that thimerosal is a very toxic substance. You are also correct in that it should be taken out of vaccines immediately. This article, in my view, shows that there are additional components in vaccines that also need serious attention.
Thank you for this excellent paper covering many relevant issues regarding vaccines and brain inflammation.
Emulsifying agents, for example polysorbates may also contribute towards the risk of brain inflammation. They are present in many vaccines in order to enhance physical stability or homogeneity regarding oily and aqueous phases.
In drug targeting polysorbate 80/Tween 80 is used to assist in the delivery of certain drugs (especially psychiatric, nano-drugs or chemotherapeutic agents) across the blood-brain barrier and into the brain tissue. Polysorbates act by rendering the barrier more porous (“open it up”).
The obvious deduction is that this is likely to happen regarding vaccines. There is a risk of, for example, the passage being facilitated of aluminium and other substances in Gardasil or of mercury in some flu vaccines of crossing the blood-brain barrier and gaining contact with the brain tissue.
It should be of special concern in the case of small children as their blood-brain barriers are not fully developed.
For further reading I highly recommend “Shaken Baby Syndrome or Vaccine-Induced Encephalitis. Are Parents Being Falsely Accused?” (ISBN 978-1-4567-1976-0)
by Harold Buttram and Christina England.
It would stand to reason if you give a vaccine meant for a healthy full term 2 month old baby to a premie that is sick, under weight and probably immature in terms of his/her immune system, that the baby would get sick from the vaccine (s).
It would seem to me that the logical thing to do would be to simply wait until the child was developmentally at the same place as an otherwise healthy, full term 2 month old before starting vaccines.
Gee, do you think maybe we need a minimum weight or level of health before we start giving vaccines to premies or low birth weight babies? What a thought!!
I’m all for vaccines in healthy, full term babies! Vaccines should be started on time and continued as normal. But the idea that you would use sick premie kids as guinea pigs to try to “prove” that vaccines are dangerous is ridiculous! Anybody with a brain in their head should be able to figure out that vaccines are meant for healthy kids at certain ages and stages of life, not for premies whose immune systems aren’t even ready to be outside the womb yet, let alone deal with a vaccine.
Laura,
Are you aware that newborn infants are given a vaccine (Hepatitis B) within 24 hours of birth? That is standard procedure anymore.
Your comment, “Anybody with a brain in their head should be able to figure out that vaccines are meant for healthy kids at certain ages and stages of life, not for premies whose immune systems aren’t even ready to be outside the womb yet, let alone deal with a vaccine”, demonstrates some of the problems that are apparent to parents and others, which the medical profession and pharmaceutical industry OUGHT to recognize and acknowledge but, in their zeal to vaccinate, apparently don’t.
Apparently our paper got you to thinking about vaccines in a way that you may not have thought before. Thank you for your comment.
Yup, that souhld defo do the trick!
The really sad thing is that a newborn baby can only get Hepatitis from it’s mother. So it would make more sense to test the mother and if she is positive, vaccinate otherwise no. But it is all about the money not the health of babies.
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I am a nurse and a mother of a one year old.
I started my search for information on vaccines and their safety when I was pregnant. I even searched while I was at work. I had one nurse ask me what I was doing and I informed her that I was considering delaying my baby's shots and she said "You are stupid." and I had a charge nurse come up to me and said that they heard I was considering delaying vaccinations. The nurse said not to because they knew someone that had not vaccinated and was all into chiropractic medicine and something had happened to the child. I can't remember the full story. Everyone is entitled to their opinion and as a parent I am trying to do the best that I can and I am sure that other parents are trying to do the best that they can.For other parents if they read this article and are just starting their search or continueing their search, I want to share some other websites that I have been to. http://www.nvic.org -National Vaccine Information Center http://www.generationrescue.org -Generation Rescue-
The Vaccine Book by Robert W. Sears is a well known book.
On February 17, 2011, Dr. Oz had a show on Autism as well.
Cont.:
I also want to say that it is hard enough trying to find a pediatrician, but it was made even harder, when trying to find one that would let me delay my child’s vaccinations. I actually had pediatricians refuse to take him, because of the vaccine delay. Even with the one I have, the first few visits the doctor basically grilled me about why I wasn’t vaccinating. Now every time I go in, the medical assistant asks any forms for “daycare” or makes comments “oh we usually give the height and weight paper with the vaccines. I have sat there waiting to be called in and no one else gets asked these things or told these things. I know it has to do with the vaccines, because I told the pediatrician I wanted to wait and I was breastfeeding (giving baby my immunity) and not placing my child in daycare (exposing baby to more illnesses. It has been frustrating & makes me want to cry at times. I just keep going though.
I forgot to say thank you to the authors.
Thank you Dr. Buttram and Catherine Frompovich.
What is the matter? You could not leave up a serious and detailed post debunking your garbage attempt at science? Essentially everything you state in this "article" is a lie, it is contradicted by the very studies you cite, evidence that you did not actually read them in the first place. If you had any integrity or honor you would reply and respond, either in private or in this forum. No, you shamefully simply delete any comments you disagree with.
I will keep this short and simple. Quit lying. Quit intentionally distorting research to support your unsupportable hypotheses. You can spread fear very effectively without undermining those of us who are actually working for better education about vaccines.
Quite frankly I think the science you talk about is part of the problem with vaccines: LIES and pseudo-science that in effect is bought and paid for by BiG Pharma and published in its SHAM 'peer reviewed' journals that they own and pay ghost writers to write and then sign MDs names to for which they paid MDs megabucks to use their name.
Please get real and stop taking the koolaid, JW Chaplin. If YOU really want to be educated, I respectfully suggest you read The Risks of Prescription Drugs, Donald W Light, PhD, Editor, Columbia University Press, available on Amazon.com. BTW: Dr. Light is at Stamford and Princeton–can't get more mainstream thinking than that, I'd say.
This makes perfect sense to me. Thank you.
Let me join in the chorus by saying Great article! VERY thought-provoking and timely. The Pourcyrous study is certainly a milestone in understanding vaccine toxicity, and thank you for presenting it. I don't know how I could have missed the article! The "cascade of biochemical events" that the authors refer to, needs to be better understood. It is likely to be shared as a common underlying pathophysiology of all vaccine toxicity. The fact that many, if not most, SIDS deaths are vaccine-induced, is a case in point.
This is a very good article, and so true. My nephew just recently had his vaccines, and not even two weeks later he was found to have a 'subdural hematoma' and their saying its child abuse. We're trying to research what could be the real cause of his 'Subdural Hematoma', because it sure wasn't abuse!! There are so many sites that I have read on about many people taking their children to get vaccinated and then they have many problems such as encephalitis, autism, and many more…
Here is a site, with many comments of those who took their children to get vaccinated and something bad happened…literally over 1,100 comments from people stating in their own words the damage it has done to their children.
Here is the link https://sites.google.com/site/redrockcloud/
My granddaughter has been taken into state custody due to allegations of child abuse after she was unresponsive to my daughters boyfriend and he rushed her to the hospital….they are claiming Shaking Baby Syndrome due to subderal hematoma and retinal bleeding, but there has absolutely not been any abuse to this little angel. She had received her second series of shots two days prior to her being unresponsive and we believe her boyfriend saved her life by rushing her to the hospital, but now no one that had contact with my granddaughter up to two weeks prior to this can have any contact. This includes natural monther, maternal and paternal grandparents, uncles, aunts, great grandparents. Everyone this little angel has known since her birth. We have a very close family and interact on a daily basis…my daughter has supervised visitation for a couple hours two days a week. She was placed in foster care and not with any of the grandparents, great grandparents, aunts and uncles that she could have been placed with, so that she could of been recovering in her own environment with the people that love her, because a social worker made a report naming all the people that had contact with her could have caused the alleged Shaking Baby Syndrome.